Stepping into the Luxury Collection’s Perry Lane Hotel in Savannah, Georgia is like entering the airy foyer of a historic Southern home. Jon Kully, owner and managing partner of Flank, the New York-based architecture and real estate development firm that built the hotel, spent five years studying the local aesthetic to achieve the look. “We’ve incorporated historic design details that harken back to the colonial era in the region,” he says.

An entry drive divides the two five-story structures that make up the 167-room hotel, which is managed by Sage Hospitality. The North Tower houses a reception space marked by dark wood millwork, black and white checkerboard floors, and rich blue grasscloth. The dreamy lounge, outfitted in leather and cream upholstery and capped by a marble fireplace, leads into the turquoise midcentury-style library. “We have been in love with high contrast sea-blue, turquoise shades, and burnt rose-type palettes, and they all made their way into this project,” says designer Kristina O’Neal, partner at New York firm AvroKO along with William Harris, Greg Bradshaw, and Adam Farmerie. In addition to Emporium Kitchen & Wine Market, which houses a grab-and-go market, café, wine bar, and spacious bistro-like restaurant, the building’s rooftop provides access to the pool and the pergola-topped Peregrine Bar, where a large-scale, colorful bird mural and river views vie for guests’ attention.

The South Tower lobby feels like a private study, complete with dark wood paneling and built-ins that showcase a worldly mix of collectibles. Next to it, the sleek Wayward Bar adds whimsy with a motorcycle suspended from the ceiling. Meanwhile, the plush guestrooms and suites have oak-floored entries, crown molding, bronze leather headboards, and “include custom love seats and window seats, as well as marble dining tables, built-in cabinetry, and armoires,” Harris notes. Curvilinear sofas and crystal pendant lights add a feminine contrast to handsome wood cabinets and deep teal walls.

One of the most intriguing aspects of the hotel, however, is the 3,600 objets d’art that take on a decidedly local flavor (among the artists who produced 1,200 artworks, 81 have ties to the nearby Savannah College of Art and Design and 75 live nearby) while also reflecting the collection of the hotel’s fictional grande dame, Adelaide Harcourt.